|Short description Levaquin (Levofloxacin) is in a group of antibiotics called fluoroquinolones. Levofloxacin fights bacteria in the body. Levofloxacin is used to treat bacterial infections of the skin, sinuses, kidneys, bladder, or prostate. Levofloxacin is also used to treat bacterial infections that cause bronchitis or pneumonia, and to treat people who have been exposed to anthrax. Levofloxacin may also be used for other purposes not listed in this medication guide.