Short description Flonase Nasal Spray (Floticasone) is a corticosteroid that works directly on the nasal passages to reduce swelling and inflammation. Fluticasone is used to relieve seasonal and year-round, allergic and non-allergic nasal symptoms such as itching, runny or stuffy nose, postnasal drip and sneezing in adults and children 4 years of age and older.