|Short description Combivir is an antiviral medication containing a combination of lamivudine and zidovudine. These medicines are in a group of human immunodeficiency virus (HIV) medicines called reverse transcriptase inhibitors. Combivir helps keep the HIV virus from reproducing in the body. Combivir is used to treat HIV, which causes the acquired immunodeficiency syndrome (AIDS). This medication is not a cure for HIV or AIDS. Combivir may also be used for purposes not listed in this medication guide.