|Short description Zetia (Ezetimide) reduces the amount of cholesterol or other sterols that your body absorbs from your diet. Generic Zetia is used to treat high cholesterol, along with a low-fat, low-cholesterol diet. It is sometimes given with other cholesterol-lowering medications. It is also used to treat high blood sitosterol and campesterol along with diet therapy. Zetia may also be used for other purposes not listed in this medication guide.